4-Aminoacetanilide → HCID 21563902, compound

HRID 1580820Notes

Reaction equation

HRID 1580820 reaction equation
Cl[C:2]1[C:10]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].[CH3:18][C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1)=[O:20]>O>[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:2]2[C:10]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=2[N+:15]([O-:17])=[O:16])=[CH:24][CH:23]=1)(=[O:20])[CH3:18]

Participants

4

Reactant 2

HCID 312304-AminoacetanilideHCID 898934-Chloro-3-nitro-5-sulphamoylbenzoic acid

Product 1

HCID 21563902HCID 21563902, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The starting material is prepared as follows: The mixture of 5.6 g of 4-chloro-3-nitro-5-sulfamoylbenzoic acid, 200 ml of water and 9 g of 4-aminoacetanilide is refluxed for four hours while stirring under nitrogen. It is cooled to room temperature and the precipitate formed filtered off, to yield the 4-(4-acetamidophenylamino)-3-nitro-5-sulfamoylbenzoic acid, melting above 275°.

Workup

  1. customThe starting material is prepared
  2. temperatureis refluxed for four hours
  3. customthe precipitate formed
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-3c01147d80bc4f699436de6b27231d37
Source dataset
uspto-grants-1976_01
Patent number
US03933906

Reaction notes

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