Sodium Hydroxide → HCID 21563923, compound

Participants

Reaction Steps

The mixture of 3.9 g of 4-(4-acetamidophenylamino)-3-benzylamino-5-sulfamoylbenzoic acid and 39 ml of 2N aqueous sodium hydroxide is refluxed for 1 hour under nitrogen. After cooling to room temperature it is filtered and the filtrate acidified with glacial acetic acid to pH = 4. The precipitate formed is filtered off and recrystallized from aqueous ethanol, to yield the 4-(4-aminophenylamino)-3-benzylamino-5-sulfamoylbenzoic acid melting at 244° with decomposition.

Provenance & Evidence