HCID 54064894, compound → HCID 21563921, compound

Participants

Reaction Steps

The mixture of 1.2 g of 4-(4-aminophenylamino)-3-furfurylamino-5-sulfamoylbenzoic acid (Example 3), 0.6 g of 10% palladium on charcoal and 120 ml of dioxane is hydrogenated at room temperature and atmospheric pressure until the theoretical amount of hydrogen has been absorbed (about 2 hours). It is filtered, the filtrate evaporated under reduced pressure, the residue is triturated with water, dissolved in 40 ml of 50% hot aqueous ethanol, the solution filtered hot, the filtrate cooled and the precipitate formed filtered off, to yield the 4-(4-aminophenylamino)-3-(2-tetrahydrofurylmethylamino)-5-sulfamoylbenzoic acid, melting at 253° with decomposition.

Provenance & Evidence