Sodium Hydroxide → HCID 54452361, compound

Participants

Reaction Steps

The mixture of 1.8 g of 4-(4-acetamidophenylamino-3-furfurylamino-5-(2-acetamidophenylsulfamoyl)-benzoic acid and 18 ml of 2 N aqueous sodium hydroxide is refluxed for 6 hours under nitrogen. After cooling to room temperature it is acidified with glacial acetic acid to a pH of 4-5, the precipitate collected and recrystallized from 6 ml of 50% aqueous ethanol, to yield the 4-(4-aminophenylamino)-3-furfurylamino-5-(2-aminophenylsulfamoyl)-benzoic acid melting at 182° with decomposition.

Provenance & Evidence