Potassium Hydroxide → HCID 54191869, compound

Participants

Reaction Steps

The starting material is prepared as follows: To the solution of 2.5 g of 4-(4-acetamidophenylamino)-3-amino-5-(4-acetamidophenylsulfamoyl)-benzoic acid in 60 ml of water and 5 ml of N potassium hydroxide, 0.7 g of 1-bromo-2-butene are added dropwise while stirring. The pH of the mixture is kept at 7.4 by subsequent addition of 4 N aqueous potassium hydroxide. After about 15 minutes the mixture is filtered, the filtrate acidified with glacial acetic acid to pH = 4, the precipitate formed filtered off and recrystallized from 50% aqueous ethanol, to yield the 4-(4-acetamidophenylamino)-3-but-2-enylamino-5-(4-acetamidophenylsulfamoyl)-benzoic acid melting at 265° with decomposition.

Provenance & Evidence