Acetophenone → HCID 21563960, compound

HRID 1580861Notes

Reaction equation

HRID 1580861 reaction equation
C(C1C=CC=CC=1)(=O)C.C(NCCCCCCNCC1C=CC=CC=1)C1C=CC=CC=1.C([N:39]([CH2:75][C:76]([C:78]1[CH:83]=[CH:82][C:81]([O:84]CC2C=CC=CC=2)=[C:80]([NH:92][C:93]([NH2:95])=[O:94])[CH:79]=1)=[O:77])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][N:46](CC1C=CC=CC=1)[CH2:47][C:48](=[O:67])[C:49]1[CH:54]=[CH:53][C:52]([O:55]CC2C=CC=CC=2)=[C:51]([NH:63][C:64]([NH2:66])=[O:65])[CH:50]=1)C1C=CC=CC=1>CC(C)=O>[OH:55][C:52]1[CH:53]=[CH:54][C:49]([CH:48]([OH:67])[CH2:47][NH:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][NH:39][CH2:75][CH:76]([OH:77])[C:78]2[CH:83]=[CH:82][C:81]([OH:84])=[C:80]([NH:92][C:93]([NH2:95])=[O:94])[CH:79]=2)=[CH:50][C:51]=1[NH:63][C:64]([NH2:66])=[O:65]

Participants

5

Reactant 3

HCID 7410AcetophenoneHCID 4074391,6-Hexanediamine, N,N'-bis(phenylmethyl)-HCID 21435552HCID 21435552, compound

Product 1

HCID 21563960HCID 21563960, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Following the procedures of Example 14, the above prepared acetophenone and N,N'-dibenzyl-hexamethylenediamine are refluxed in acetone for 12 hours and the resulting N,N'-dibenzyl-N,N'-bis[2-(4-benzyloxy-3-ureidophenyl)-2-oxoethyl]-hexamethylenediamine is hydrogenated to yield N,N'-bis[2-(4-hydroxy-3-ureidophenyl)-2-hydroxyethyl]-hexamethylenediamine.

Sources & evidence

ORD record
ord-deee6804ac4b4a599c8d618c8b45a5a8
Source dataset
uspto-grants-1976_01
Patent number
US03933913

Reaction notes

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