Z-Thr(tBu)-Gln-Asn-Phe-OCH3 → H-Thr(tBu)-Gln-Asn-Phe-OCH3

HRID 1580892Notes

Reaction equation

HRID 1580892 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:38]([O:40][CH3:41])=[O:39])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:28])[CH2:23][C:24](=[O:26])[NH2:25])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>CO.[C].[Pd]>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:38]([O:40][CH3:41])=[O:39])[CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)=[O:28])[CH2:23][C:24](=[O:26])[NH2:25])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:7])([CH3:6])[CH3:8]

Participants

4

Reactant 1

HCID 131709991Z-Thr(tBu)-Gln-Asn-Phe-OCH3

Product 1

HCID 131709992H-Thr(tBu)-Gln-Asn-Phe-OCH3

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

6.31 g of Z-Thr(tBu)-Gln-Asn-Phe-OCH3 and 700 mg of palladium carbon are hydrogenated together at room temperature in 600 ml of methanol in a shaking vessel. The substance gradually passes into solution. The amorphous evaporation residue is used for the next condensation as it is.

Workup

  1. customThe amorphous evaporation residue is used for the next condensation as it

Sources & evidence

ORD record
ord-38a7d939df394553a600e38ef2520130
Source dataset
uspto-grants-1976_01
Patent number
US03934008

Reaction notes

Loading…