HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform methanol → tert-Butyl L-alanyl-L-prolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-alanyl-L-proline 1,1-dimethylethyl ester | HCID 54380188 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl L-alanyl-L-prolinate | HCID 12939800 | — |
Reaction Steps
9.36 g of Z-Ala-Pro-OtBu are hydrogenated in 100 ml of methanol in the presence of 500 mg of Pd on charcoal (10 %) at room temperature. The hydrogen uptake has ended after 90 minutes. The solution is freed of catalyst by filtration and evaporated in a waterpump vacuum at 30°C to give an oil. This proves to be homogeneous in a thin layer chromatogram on silica gel. Rf = 0.35 in the system chloroform-methanol (1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03934008 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-40f98bad303a48e9be881d8d09e6eb29 |
| Source note | uspto-grants-1976_01 |