HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform methanol → H-Val-Gly-Ala-Pro-OtBu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | Z-Val-Gly-Ala-Pro-OtBu | HCID 131709999 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | H-Val-Gly-Ala-Pro-OtBu | HCID 131710000 | — |
Reaction Steps
533 mg of Z-Val-Gly-Ala-Pro-OtBu are hydrogenated in 10 ml of methanol in the presence of 300 mg of Pd on charcoal (10%) at room temperature. The hydrogen uptake has ended after 20 minutes. The catalyst is filtered off and the filtrate evaporated in a waterpump vacuum at 30°C to give an oil. Rf = 0.52 in the system chloroform-methanol (1:1) on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03934008 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-0619c9f01117476a87dcc54c7ed798f0 |
| Source note | uspto-grants-1976_01 |