HCID 131710008, compound → Glycine, N-(N-L-methionyl-L-leucyl)-

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Reaction Steps

6.9 g of BOC-Met-Leu-Gly-OH are dissolved in 70 ml of 90 % strength trifluoracetic acid and left to stand for one hour at 20°C. Thereafter the solution is concentrated, mixed with 150 ml of ether whilst stirring and left to stand overnight at -10°C. The resulting precipitate is filtered off and again stirred with 100 ml of ether, filtered off, twice washed with ether and dried in vacuo over sodium hydroxide. Melting point 134°-135°C; Rf7 = 0.52 (on silica gel).

Provenance & Evidence