3,4,5-Trimethoxybenzaldehyde → HCID 56616028, compound

Participants

Reaction Steps

To a solution of 2.2g of sodium methoxide in 100ml of absolute methanol is added 3.5g of 2,9-dimethyl-4H-pyrido-[1,2-a]pyrimidin-4-one, followed by 4.0g of 3,4,5-trimethoxybenzaldehyde. The mixture is stirred and heated under reflux for 28 hours. A crystalline solid separates and this is colled and filtered. The solid consists of a mixture of colorless and yellow crystals that are separated manually to give 1.52g of a pale yellow solid, melting point 208° - 210°C. The yellow solid is recrystallized from 35ml of methoxyethanol to yield 1.22g of the title compound, melting point 212°-214°C.

Provenance & Evidence