2-Methyl-4H-pyrido[1,2-a]pyrimidin-4-one → HCID 12338960, compound

HRID 1580939Notes

Reaction equation

HRID 1580939 reaction equation
C[O-].[Na+].[CH3:4][C:5]1[N:6]=[C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][N:8]2[C:9](=[O:11])[CH:10]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([C:28]2C=CC=CC=2C=O)[CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25]>C(O)C>[CH3:27][O:26][C:22]1[CH:21]=[C:20](/[CH:28]=[CH:4]/[C:5]2[N:6]=[C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][N:8]3[C:9](=[O:11])[CH:10]=2)[CH:19]=[C:18]([O:17][CH3:16])[C:23]=1[O:24][CH3:25]

Participants

5

Reactant 3

HCID 2780932-Methyl-4H-pyrido[1,2-a]pyrimidin-4-oneHCID 10942334Sodium MethoxideHCID 21560651HCID 21560651, compound

Product 1

HCID 12338960HCID 12338960, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.3g of sodium methoxide in 75ml of absolute ethanol is added 3.2g of 2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one, followed by 4.0g of 3,4,5-trimethoxyphenyl-benzaldehyde. The mixture is stirred and heated under reflux for 24 hours. The mixture is worked up as described in Example 3 to yield the title compound, melting point 212°-214°C, dec.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 24 hours

Sources & evidence

ORD record
ord-f53a1054f01f4751b82ed8b18fd1ec25
Source dataset
uspto-grants-1976_01
Patent number
US03935197

Reaction notes

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