Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 178502647, compound

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Reaction Steps

To a solution of N,O-dimethylhydroxylamine hydrochloride (7.7g) in water (40 ml) was added, firstly, sodium bicarbonate (6.5 g) and, secondly, 4-hydroxy-6-methyl-2-nitraminopyrimidine (10.8 g) and the resultant mixture was heated at 100°C for 2 hours. After filtering hot to remove traces of insoluble material the filtrate was cooled and extracted with chloroform (12 × 25 ml). The extracts were dried over anhydrous sodium sulphate and the solvent evaporated. The residual solid was recrystallised twice from benzene to yield 4-hydroxy-6-methyl-2(N-methyl-N-methoxyamino) pyrimidine having a melting point of 128°-129°C.

Provenance & Evidence