HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,2-Diamino-4-(pyrimidin-2-ylthio)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | 2-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline | HCID 21482775 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1,2-Diamino-4-(pyrimidin-2-ylthio)benzene | HCID 21482779 | — |
Reaction Steps
3.5 G. of 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene is treated with 16 g. stannous chloride in 16 ml. concentrated hydrochloric acid on the steam bath for 30 minutes. The mixture is cooled, treated with an excess of potassium bicarbonate, chloroform, and filtered. The chloroform layer is dried and stripped yielding 1,2-diamino-4-(pyrimidin-2-ylthio)benzene which may be recrystallized from benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03935209 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-b1c761c4e7bf4b47a96937df1431a9ef |
| Source note | uspto-grants-1976_01 |