Phosphorus sulfide (P2S5) → HCID 13248013, compound

Participants

Reaction Steps

A mixture of 6 g of ethyl 3-(3,4-dimethoxybenzyl)-4-(3,4-dimethoxyphenyl)-2-oxo-3-pyrrolidinecarboxylate, 4 g of diphosphorus pentasulfide and 120 ml of anhydrous benzene is refluxed with stirring for one hour. While it is hot, the insoluble matter is filtered off, and the filtrate is concentrated under reduced pressure. The residue is washed with water and recrystallized from ethanol to give 5.4 g of ethyl 3-(3,4-dimethoxybenzyl)-4-(3,4-dimethoxyphenyl)-2-thioxo-3-pyrrolidinecarboxylate as white crystalline powder, melting at 166°-169°C.

Provenance & Evidence