HCID 21560878, compound → HCID 21560923, compound

HRID 1580985Notes

Reaction equation

HRID 1580985 reaction equation
[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:25])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]2[NH:21][CH2:22][CH2:23][N:24]=2)=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].NC1C=CC(C=O)=C(C2NCCN=2)C=1.ClC1C=CC(C(=O)CC2C=CC=CC=2)=C(C2NCCN=2)C=1.N1CCN=C1C1C=CC=CC=1C1C=CSC=1C(C1SC=CC=1C1C=CC=CC=1C1NCCN=1)=O>>[CH2:1]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2([OH:25])[C:14]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:20]3=[N:21][CH2:22][CH2:23][N:24]23)=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 4

HCID 21560878HCID 21560878, compoundHCID 21560882HCID 21560882, compoundHCID 21560963HCID 21560963, compoundHCID 21560965HCID 21560965, compound

Product 1

HCID 21560923HCID 21560923, compound

Procedure

In a similar manner, the following sulfates are synthesized: 4'-hexyl-2-(2-imidazolin-2-yl)benzophenone; 4-amino-2-(2-imidazolin-2-yl)benzaldehyde; 4'-chloro-2'-(2-imidazolin-2-yl)-2-phenylacetophenone; and 2-(2-imidazolin-2-yl)phenyl-2-thienyl ketone which are then contacted with a base to respectively afford the following: 5-(4-hexylphenyl)2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol; 8-amino-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol; 8-chloro-5-(4-ethylphenyl)-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol; and 2,3-dihydro-5-(2-thienyl)-5H-imidazo[2,1-a]isoindol-5-ol.

Sources & evidence

ORD record
ord-9760d8f505734e15b63850720e5324fa
Source dataset
uspto-grants-1976_01
Patent number
US03935218

Reaction notes

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