反应详情

24 g. of 1-(4'-chloro benzyl)-2-phenyl-4-(β-hydroxy ethyl) piperazine are dissolved in 150 cc. of chloroform and added drop by drop to a solution of 15 g. of thionyl chloride in 150 cc. of chloroform. The mixture is boiled under reflux for 5 hours and the solvent is removed in a vacuum by heating the mixture in a water bath. Excess of absolute ethanolic hydrochloric acid is added and the remaining acid is distilled off. The crystalline residue obtained is recrystallized from absolute ethanol. Melting point 178°-195° C. (dec.); yield 30 g.

1. temperatureunder reflux for 5 hours
2. customthe solvent is removed in a vacuum
3. temperatureby heating the mixture in a water bath
4. additionExcess of absolute ethanolic hydrochloric acid is added
5. distillationthe remaining acid is distilled off
6. customThe crystalline residue obtained
7. customis recrystallized from absolute ethanol