Nitric Acid → HCID 19097121, compound

Participants

Reaction Conditions

Reaction Steps

51.3 parts of 2-formylaminothiophene-3-carboxylic acid are added to 500 parts of sulphuric acid (sp.gr. 1.84) at a temperature below 10°C, and 56.7 parts of a nitrating mixture (obtained by mixing together 633 parts of 20% oleum and 348 parts of nitric acid of sp.gr. 1.50) are then slowly added, the temperature of the mixture being maintained at -10° to -5°C by external cooling. The mixture is stirred for 5 minutes at -5°C, poured into an ice/water mixture and the precipitated 2-formylamino-5-nitrothiophene-3-carboxylic acid (90% yield) is filtered off, washed with water and dried.

Provenance & Evidence