(+-)-Pantolactone → Calcium Pantothenate, Racemic

HRID 1581050Notes

Reaction equation

HRID 1581050 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]([O-:6])=[O:5].[Ca+2:7].[NH2:8][CH2:9][CH2:10][C:11]([O-:13])=[O:12].[CH3:14][C:15]1([CH3:22])[CH:20]([OH:21])[C:18](=[O:19])[O:17][CH2:16]1>CO>[CH3:14][C:15]([CH:20]([OH:21])[C:18]([NH:1][CH2:2][CH2:3][C:4]([O-:6])=[O:5])=[O:19])([CH2:16][OH:17])[CH3:22].[CH3:14][C:15]([CH:20]([OH:21])[C:18]([NH:8][CH2:9][CH2:10][C:11]([O-:13])=[O:12])=[O:19])([CH2:16][OH:17])[CH3:22].[Ca+2:7]

Participants

4

Reactant 2

HCID 989(+-)-PantolactoneHCID 161901beta-Alanine, Calcium Salt (2:1)

Product 1

HCID 8714Calcium Pantothenate, Racemic

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

reacting the anhydrous calcium beta-alaninate with dl-pantolactone in methanol at a temperature of from about 55° to about 65° C. for from about 6 to about 9 hours and therafter cooling and filtering the reaction product and removing methanol to obtain dl-calcium pantothenate.

Workup

  1. customof from about 55° to about 65° C.
  2. customfor from about 6 to about 9 hours
  3. filtrationtherafter cooling and filtering the reaction product
  4. customremoving methanol

Sources & evidence

ORD record
ord-60af56a37c3045d2aae9931090884190
Source dataset
uspto-grants-1976_01
Patent number
US03935256

Reaction notes

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