4-Fluorobenzene-1,2-diamine → HCID 178512596, compound

HRID 1581149Notes

Reaction equation

HRID 1581149 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.[C:10]([NH:12][C:13]([NH2:15])=[NH:14])#N>>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]=[C:10]([NH:12][C:13]([NH2:15])=[NH:14])[NH:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 1645844-Fluorobenzene-1,2-diamineHCID 178418324HCID 178418324, compound

Product 1

HCID 178512596HCID 178512596, compoundYield 72.9%

Procedure

4-Fluoro-o-phenylenediamine (10.40g) was reacted with cyanoguanidine (6.95g) in a manner analagous to that described in Example 3 to yield a brown crystaline precipitate (11.61g) which on crystalisation from water yielded 5-fluoro-2-quanidinobenzimidazole (9.17g) m.p. 217°-218°C as brown needles.

Sources & evidence

ORD record
ord-1ff447f1f3804d55a5ed9db36f9066ec
Source dataset
uspto-grants-1976_01
Patent number
US03935314

Reaction notes

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