4-Trifluoromethyl-1,2-phenylenediamine → HCID 178512595, compound

HRID 1581150Notes

Reaction equation

HRID 1581150 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([NH2:10])[CH:4]=1.[C:13]([NH:15][C:16]([NH2:18])=[NH:17])#N>>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:8]=[CH:7][C:6]2[N:9]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[NH:10][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 5208224-Trifluoromethyl-1,2-phenylenediamineHCID 178418324HCID 178418324, compound

Product 1

HCID 178512595HCID 178512595, compound

Procedure

4-Trifluoromethyl -o- phenylenediamine (25.46g) and cyanoguanidine (12.40g) were reacted together in a manner analogous to that of Example 2 to yield 5-Trifluoromethyl-2-guanidinobenzimidazole is a red gummy solid which when dissolved in 5N hydrochloroic acid and evaporated to dryness yielded the dihydrochloride (25.01g) as a brown solid, m.p. 206°-209°C.

Sources & evidence

ORD record
ord-0e673b892f664bd28b584c82b8456024
Source dataset
uspto-grants-1976_01
Patent number
US03935314

Reaction notes

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