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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 158143Generated: October 26, 2026

Acetic Acid → 2-(7-Chloro-1,8-naphthyridin-2-yl)-5-chloro-3-hydroxy-isoindolin-1-one

https://huagongshe.com/reaction/158143

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPotassium CationHCID 813—
ReactantMethanolHCID 887—
ReactantDimethylformamideHCID 6228—
ReactantPhosphorus oxychlorideHCID 24813—
ReactantBorohydrideHCID 28123—
Reactant1,4-DioxaneHCID 31275—
Reactant4-Chlorophthalic anhydrideHCID 67044—
Reactant6-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinoneHCID 19842241—
Reactant2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-5-chloro-isoindolin-1-oneHCID 21422118—
Reactant2-(7-Chloro-1,8-naphthyridin-2-yl)-5-chlorophthalimideHCID 22754745—
ReactantHCID 178507296HCID 178507296—
ReactantHCID 178518247HCID 178518247—
Product2-(7-Chloro-1,8-naphthyridin-2-yl)-5-chloro-3-hydroxy-isoindolin-1-oneHCID 19842242—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-58143aed2e8e49119d781879d51b0eb8
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)