2-Phenylbutyric Acid → HCID 22721585, compound

HRID 1581463Notes

Reaction equation

HRID 1581463 reaction equation
[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(CC)C(O)=O)C=CC=CC=1.[Mg+2:25].[Cl-:26].[Cl-]>C1(C)C=CC=CC=1>[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([O-:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-:26].[Mg+2:25]

Participants

4

Reactant 2

HCID 70122-Phenylbutyric AcidHCID 86759437HCID 86759437, compound

Product 1

HCID 22721585HCID 22721585, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

5.52 g (51.6 mmoles) of the support obtained as already described, are suspended in 300 ml of toluene, operating in a stirred 1,000 ml reactor. 16.9 g (103.2 mmoles) of 2-phenylbutyric acid dissolved in 150 ml of anhydrous toluene (with a molar ratio phenylbutyric acid/MgCl2 equal to 2.0) are slowly added, under stirring, to the suspension obtained, kept at room temperature. At the end of the addition, nitrogen is bubbled in for 3 hours. The residue is filtered on a sintered glass septum.

Workup

  1. custom5.52 g (51.6 mmoles) of the support obtained
  2. customoperating in a stirred 1,000 ml reactor
  3. additionare slowly added
  4. customobtained
  5. customkept at room temperature
  6. additionAt the end of the addition, nitrogen
  7. customis bubbled in for 3 hours
  8. filtrationThe residue is filtered on a sintered glass septum

Sources & evidence

ORD record
ord-36492f2692dd43f6bd6c0860bd514f42
Source dataset
uspto-grants-2004_05
Patent number
US06730627B1

Reaction notes

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