Sodium borohydride → HCID 22506963, compound

HRID 1581500Notes

Reaction equation

HRID 1581500 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][S:10]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[NH:17][N:18]=2)(=[O:12])=[O:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:20])[CH2:9][S:10]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[NH:17][N:18]=2)(=[O:12])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22506968HCID 22506968, compound

Product 1

HCID 22506963HCID 22506963, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension was prepared of 6-[2-(4-chloro-phenyl)-2-oxo-ethanesulfonyl]-2H-pyridazin-3-one (1.0 mmol, 312 mg) prepared according to Example 17 in methanol (10 mL). Sodium borohydride (1.5 mmol, 55 mg) was added to the suspension at room temperature and stirred for 1 hour. The reaction mixture was evaporated and the residue was triturated with 10% hydrochloric acid (5 mL). The resulting white precipitate was filtered and air-dried to afford the title compound (69%, 218 mg); mp, 178-179° C.

Workup

  1. customprepared
  2. customThe reaction mixture was evaporated
  3. customthe residue was triturated with 10% hydrochloric acid (5 mL)
  4. filtrationThe resulting white precipitate was filtered
  5. customair-dried

Sources & evidence

ORD record
ord-e9a3f4300c184e979228881ce528f2ca
Source dataset
uspto-grants-2004_05
Patent number
US06730674B2

Reaction notes

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