HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Benzyl 4-methylidenepyrazolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzyl tert-butyl 4-methylidenepyrazolidine-1,2-dicarboxylate | HCID 12970152 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzyl 4-methylidenepyrazolidine-1-carboxylate | HCID 12970153 | 97% |
Reaction Steps
To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 8, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730668B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-e50c2ec85f0a4c17a633d247356f90c7 |
| Source note | uspto-grants-2004_05 |