反应详情

2-[2—(4-Fluorophenyl)acetyl]4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester, 46, (12.0 g, 32.2 mmol) is dissolved in methyl alcohol (300 mL). The flask is flushed with nitrogen and charged with 10% palladium on carbon (1.2 g). The reaction mixture is stirred vigorously at room temperature under 1 atmosphere of hydrogen gas for 3 hours. The flask is flushed with nitrogen and the reaction mixture filtered through a pad of Celite, rinsing with ethyl acetate (100 mL). The filtrate is concentrated in vacuo to afford 7.67 g of the desired product as a viscous, clear oil.

1. customThe flask is flushed with nitrogen
2. additioncharged with 10% palladium on carbon (1.2 g)
3. customThe flask is flushed with nitrogen
4. filtrationthe reaction mixture filtered through a pad of Celite
5. washrinsing with ethyl acetate (100 mL)
6. concentrationThe filtrate is concentrated in vacuo