HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 5-Hydroxy-3-iodo[1,7]naphthyridine-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl 2-(((2-Ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate | HCID 22722035 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5-Hydroxy-3-iodo[1,7]naphthyridine-6-carboxylate | HCID 135744203 | — |
Reaction Steps
A mixture of ethyl 2-(((2-ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate (Preparation 11, 8.20 g) and sodium ethoxide (2.6 g) in anhydrous ethanol (60 mL) is stirred for 5 h. The mixture is then poured into water and neutralized with 3 N aqueous hydrochloric acid. The resulting precipitate is filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730682B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-cd4629dc26f94ddcac88b9258bcb55f3 |
| Source note | uspto-grants-2004_05 |