HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-piperidinecarboxylate → 1-(4-Pyrimidinyl)-4-(ethoxycarbonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 4-Chloropyrimidine hydrochloride | HCID 21922556 | — |
| Product | 1-(4-Pyrimidinyl)-4-(ethoxycarbonyl)piperidine | HCID 22721957 | 46% |
Reaction Steps
Using an analogous procedure to that described in Example 32, 4-chloropyrimidine hydrochloride was reacted with ethyl piperidine-4-carboxylate to give ethyl 1-(4-pyrimidinyl)piperidine-4-carboxylate in 46% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730672B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-486c0a06eab540869637098c2f98f92a |
| Source note | uspto-grants-2004_05 |