HRID1581605

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7383

Benzenesulfonyl chloride, 3,4-dichloro-

C6H3Cl3O2S

结构：Cl.NCC(=O)NC(CNC(=O)C1CCN(c2ccncc2)CC1)C(=O)N1CCCCC1

HCID21999976

未命名化合物

PRODUCTS

生成物

结构：O=C(CNS(=O)(=O)c1ccc(Cl)c(Cl)c1)NC(CNC(=O)C1CCN(c2ccncc2)CC1)C(=O)N1CCCCC1

HCID22721953

未命名化合物

收率 27%

PROCEDURE

实验过程

Using an analogous procedure to that described in Example 2, 2-amino-N-{1-piperidinocarbonyl-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide hydrochloride salt was reacted with 3,4-dichlorophenylsulphonyl chloride to give 2-(3,4-dichlorophenylsulphonamido)-N-{1-piperidinocarbonyl-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide as a gum (0.17 g, 27%);

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-88f939a915df437fa4bc8c494c1baf3f
来源数据集: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06730672B2
来源说明: uspto-grants-2004_05

反应 SMILES

Cl.[NH2:2][CH2:3][C:4]([NH:6][CH:7]([C:24]([N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:25])[CH2:8][NH:9][C:10]([CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH2:14][CH2:13]1)=[O:11])=[O:5].[Cl:32][C:33]1[CH:34]=[C:35]([S:40](Cl)(=[O:42])=[O:41])[CH:36]=[CH:37][C:38]=1[Cl:39]>>[Cl:32][C:33]1[CH:34]=[C:35]([S:40]([NH:2][CH2:3][C:4]([NH:6][CH:7]([C:24]([N:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)=[O:25])[CH2:8][NH:9][C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])=[O:5])(=[O:41])=[O:42])[CH:36]=[CH:37][C:38]=1[Cl:39]