HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthalenesulfonyl chloride → Methyl 2-[4-benzyl-1-(2-naphthylsulphonyl)piperazin-2-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthalenesulfonyl chloride | HCID 7125 | — |
| Reactant | 2-Piperazineacetic acid, 4-(phenylmethyl)-, methyl ester | HCID 15665466 | — |
| Product | Methyl 2-[4-benzyl-1-(2-naphthylsulphonyl)piperazin-2-yl]acetate | HCID 22721938 | 90% |
Reaction Steps
Using an analogous procedure to that described in Example 2, methyl 2-(1-benzylpiperazin-3-yl)acetate (J. Chem. Soc. Perkin I, 1992, 1035) was reacted with 2-naphthylsulphonyl chloride to give methyl 2-[4-benzyl-1-(2-naphthylsulphonyl)piperazin-2-yl]acetate in 90% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730672B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-de9b63d6f09a47f4a394cd364525d87f |
| Source note | uspto-grants-2004_05 |