Dichloromethane → 3-(2-Fluorophenyl)-5-(morpholin-4-yl)-[1,2,3]triazolo[1,5-a]quinazoline

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Reaction Steps

A solution of 3-(2-fluorophenyl)-5-(4-methylbenzenesulfonyloxy)-[1,2,3]triazolo[1,5-α]quinazoline (0.10 g, 0.23 mmol), triethylamine (0.10 ml, 0.7 mmol) and morpholine (0.025 g, 0.25 mmol) in dry N,N-dimethylformamide (2 ml) was stirred at 50° C. under nitrogen for 18 h. The mixture was cooled, then diluted with water (10 ml) and 10% methanol:dichloromethane (5 ml). The two phases were separated by filtration through a PTFE membrane and the organic layer was concentrated. Trituration and washing with ethyl acetate-diethyl ether gave 3-(2-fluorophenyl)-5-(morpholin-4-yl)-[1,2,3]triazolo[1,5-α]quinazoline (0.065 g, 81%). δH (360 MHz; DMSO) 3.61 (4H, dd, J=5 and 5), 3.86 (4H, dd, J=5 and 5), 7.34-7.39 (2H, m), 7.42-7.50 (1H, m), 7.77 (1H, dd, J=7 and 7), 8.04-8.10 (2H, m), 8.22 (1H, d, J=8), 8.59 (1H, d, J=8); m/z (ES+) 350 (M+H+).

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