5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine → HCID 10201162, compound

HRID 1581630Notes

Reaction equation

HRID 1581630 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12.[F:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]1[N:21]=[N:22][C:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])=[C:16]1[N:15]=[C:14]2OS(C1C=CC(C)=CC=1)(=O)=O>>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][N:7]([C:14]3[C:13]4[C:18](=[CH:19][CH:20]=[C:11]([F:10])[CH:12]=4)[N:17]4[N:21]=[N:22][C:23]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=5[F:30])=[C:16]4[N:15]=3)[CH2:6][C:5]=12

Participants

3

Reactant 2

HCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazineHCID 86587353HCID 86587353, compound

Product 1

HCID 10201162HCID 10201162, compound

Procedure

Prepared from 5,6,7,8-tetrahydroimidazo[1,2-α]pyrazine and 7-fluoro-3-(2-fluorophenyl)-5-(4-methylbenzenesulfonyloxy)-[1,2,3]triazolo[1,5-α]quinazoline as described for Example 1, step c (0.031 g, 26%). Found: C, 61.72; H, 3.79; N, 23.14. C21H15F2N7.0.33(H2O) requires C, 61.65; H, 3.86; N, 23.96%. δH (360 MHz; CDCl3) 4.09 (2H, dd, J=5 and 5), 4.05 (2H, dd, J=5 and 5), 4.97 (2H, s), 6.93 (1H, d, J=1), 7.07 (1H, d, J=1), 7.21-7.32 (2H, m), 7.37-7.40 (1H, m), 7.67-7.74 (2H, m), 8.06 (1H, ddd, J=7, 7 and 2), 8.75 (1H, dd, J=8 and 5); m/z (ES+) 404 (M+H+).

Sources & evidence

ORD record
ord-8b3522b0bd634658ab7447bba9ac0e37
Source dataset
uspto-grants-2004_05
Patent number
US06730681B2

Reaction notes

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