Acetic Acid → HCID 2850570, compound

Participants

Reaction Steps

4-Methoxy-3-nitrobenzaldehyde (4.00 g, 22.2 mmol), thiazolidine-2,4-dione (3.10 g, 26.5 mmol), ammonium acetate (3.40 g, 44.1 mmol), acetic acid (8 mL) and benzene (120 mL) were mixed, and, while removing water formed by the reaction, the mixture was refluxed for 8 hours. After allowed to stand for cooling, the precipitated crystals were collected by filtration, washed with benzene and 20% aqueous acetone, and then dried to obtain 5.50 g (88%) of the title compound as yellow powder.

Provenance & Evidence