Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | HCID 22722138 | HCID 22722138 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22722139 | HCID 22722139 | — |
Reaction Steps
Anhydrous hydrazine (2.02 mL, 1.4 eq) was dissolved in acetonitrile (100 μL) and cooled to 0° C. Triethylamine (12.8 mL, 2.0 eq.) was added followed by 1-(4-chlorophenyl)cyclobutanecarbonyl fluoride (10 g, 1.0 eq) in acetonitrile (25 mL). After stirring at room temperature for one hour the acetonitrile was removed by evaporation. Product was obtained after silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06730690B2 |
|---|
| Source dataset | uspto-grants-2004_05 |
|---|
| ORD ID | ord-130eda7459604f2b9bb0d3ca5e45a86f |
|---|
| Source note | uspto-grants-2004_05 |
|---|
