反应详情

The product from Example 3 is dissolved in acetic acid-water (1:2, 3 mL) and sodium cyanate (2 mmol) added. This is stirred until a brownish gum is precipitated. The mixture is extracted with chloroform (3×30 mL), and the organic extracts washed with saturated sodium bicarbonate, dried with magnesium sulfate and the solvent evaporated in vacuo. The resulting product is purified by reverse-phase HPLC as above.

1. customis precipitated
2. extractionThe mixture is extracted with chloroform (3×30 mL)
3. washthe organic extracts washed with saturated sodium bicarbonate
4. dry with materialdried with magnesium sulfate
5. customthe solvent evaporated in vacuo
6. customThe resulting product is purified by reverse-phase HPLC as above