Allyl chloroformate → HCID 9922403, compound

HRID 1581723Notes

Reaction equation

HRID 1581723 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15].Cl[C:18]([O:20][CH2:21][CH:22]=[CH2:23])=[O:19]>>[CH2:21]([O:20][C:18](=[O:19])[NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])[CH:22]=[CH2:23]

Participants

3

Reactant 2

HCID 18052Allyl chloroformateHCID 22722278N-[2-(5-Amino-1H-indol-3-yl)ethyl]acetamide

Product 1

HCID 9922403HCID 9922403, compound

Procedure

The product from example 3 (5 mmol) is then treated with allyl chloroformate in the same manner as above, and purified on silica gel with 5% methanol in chloroform as eluent.

Workup

  1. custompurified on silica gel with 5% methanol in chloroform as eluent

Sources & evidence

ORD record
ord-9979668b4e024acebc94dc57c8b46134
Source dataset
uspto-grants-2004_05
Patent number
US06730707B2

Reaction notes

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