Isopropanol → HCID 14973176, compound

Participants

Reaction Conditions

Reaction Steps

8.21 g of 2-indanone (Aldrich, 98%, Mw=132.16, 60.88 mmol), 40 mL of isopropanol, 10.84 g of p-methoxyphenylhydrazin hydrochloride (Aldrich, 98%, Mw=174.63, 60.83 mmol) were charged at room temperature in a 250 mL flask equipped with magnetic stirrer. The slurry was brought to reflux (82° C.), (a black slurry was obtained), and kept at reflux for 1 hour. The dark brown viscous suspension was then cooled to room temperature; 200 mL of water saturated with NaHCO3 were added into the reactor (final pH ca. 7.5-8), the resulting mixture was filtered and the residue washed with plenty of water. The dark green solid on the filter was dried in vacuo at 70° C. for 4 hours (14 g, 98.9% pure by GC, 96.7% yield of pure product).

Provenance & Evidence