Ethyl 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoate → 1-(4-ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine

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Reaction Steps

MnO2 (100 g, 1.15 mol) was loaded into a flask, followed by 1-(4-ethoxy-3-hydroxymethylphenylsulfonyl)-4-methylpiperazine (15 g, 0.05 mol, from step (b) above). This was washed with acetone (150 mL) and the suspension stirred for 3 hours. The MnO2 was filtered off onto Celite® and the filtrate concentrated under vacuum to give a pale yellow oil. This was recrystallised from toluene to give the title compound as a pale green solid (7.4 g, 47%).

Provenance & Evidence