1,10-Phenanthroline → HCID 11809738, compound

Participants

Reaction Steps

Another embodiment of the process comprises mixing a solution of 1,10-phenanthroline in THF with a solution of samarium diiodide in THF and adding to the mixed solutions a solution of the chiral bicyclic ketone, (−)-thujone, in THF. The chiral product, 2-{(1S,3R,4S,5R)-(3-hydroxy-1-isopropyl-4-methylbicyclo[3.1.0]hex-3-yl)}-1,10-phenanthroline, is isolated and purified as described above in the preceding embodiment. This embodiment is illustrated by the following reaction scheme.

Provenance & Evidence