1,10-Phenanthroline → HCID 12994068, compound

Participants

Reaction Steps

An embodiment of the above described 2-step process is shown in the following reaction scheme wherein R is hydrogen and 2-[(1-hydroxy-1-methylpropyl)]-1,10-phenanthroline is prepared by coupling methyl ethyl ketone with 1,10-phenanthroline, and the coupling product alkylated with methyl iodide and sodium hydride to form 2-[(1-methoxy-1-methylpropyl)]-1,10-phenanthroline. The latter is reduced with the lanthanideII reducing agent, samarium diiodide, to provide 2-(1-methylpropyl)-1,10-phenanthroline.

Provenance & Evidence