HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone → 3-Chloromethylthio-7-fluoro-1-methyl-4-quinolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone | HCID 10445996 | — |
| Reactant | (S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone | HCID 10445997 | — |
| Reactant | 7-Fluoro-1-methyl-3-methylthio-4-quinolone | HCID 86589151 | — |
| Product | 3-Chloromethylthio-7-fluoro-1-methyl-4-quinolone | HCID 10445208 | — |
Reaction Steps
FIG. 9 depicts the second step in the synthesis of e.e.(S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone and (R)-(−)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone. In this step, 7-fluoro-1-methyl-3-methylthio-4-quinolone is chlorinated as described to produce 3-chloromethylthio-7-fluoro-1-methyl-4-quinolone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730790B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-ba704b18a28a44fc8338f68904a66385 |
| Source note | uspto-grants-2004_05 |