HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1581782Generated: November 1, 2026
Sodium Hydroxide → 3-(4,5-Dihydro-1H-imidazol-2-yl)phenol
https://huagongshe.com/reaction/1581782
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-Hydroxybenzoate | HCID 88068 | — |
| Reactant | 1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) | HCID 225030 | — |
| Product | 3-(4,5-Dihydro-1H-imidazol-2-yl)phenol | HCID 16218165 | 22.3% |
Reaction Steps
A mixture of methyl 3-hydroxybenzoate (5.48 g, 36.0 mmol) and 1,2-diaminoethane monotosylate (9.85 g, 42.4 mmol) is heated at 210° C. for 7 hours. After cooling, the mixture is stirred with aqueous 2N sodium hydroxide and extracted with ethyl acetate. The precipitate which formed and is present in the aqueous layer is collected by filtration and dried in vacuo to give 1.3 g (22%) of 2-(3-hydroxyphenyl)imidazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06730792B2 |
|---|
| Source dataset | uspto-grants-2004_05 |
|---|
| ORD ID | ord-7785899d448841c499729958b4af60f4 |
|---|
| Source note | uspto-grants-2004_05 |
|---|
