化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-(2-methoxyphenyl)propenal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 2-Methoxyphenethyl alcohol | HCID 81909 | — |
| 反応物 | 2-(2-Methoxyphenyl)acetaldehyde | HCID 269548 | — |
| 生成物 | 2-(2-Methoxyphenyl)acetaldehyde | HCID 269548 | — |
| 生成物 | 3-Dimethylamino-2-(2-methoxyphenyl)propenal | HCID 86589913 | 90% |
反応手順
(2-Methoxyphenyl)acetaldehyde is prepared by oxidation of 2-(2-methoxyphenyl)ethanol according to the procedure disclosed in J. Org. Chem., 49:1720, 1999. A mixture of (2-methoxyphenyl)acetaldehyde (3.8 g, 25.3 mmol) and dimethylformamide dimethyl acetal (4.52 g, 37.9 mmol) is stirred at room temperature for 1 hour. Excess of the acetal is removed under reduced pressure to leave 4.68 g of 3-dimethylamino-2-(2-methoxyphenyl)propenal (90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06730792B2 |
| 出典データセット | uspto-grants-2004_05 |
| ORD ID | ord-b8268a6c788a4d04ad8f2aa6685f2fc2 |
| 出典メモ | uspto-grants-2004_05 |