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Hydrazine hydrate (1:1) → 4-(2-Methoxyphenyl)-1H-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 3-Dimethylamino-2-(2-methoxyphenyl)propenal | HCID 86589913 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(2-Methoxyphenyl)-1H-pyrazole | HCID 22723470 | 68% |
反応手順
A solution of 3-dimethylamino-2-(2-methoxyphenyl)propenal (4.68 g, 22.8 mmol) and hydrazine hydrate (6.7 ml) in ethanol (100 ml) is heated at reflux for 30 minutes. The solvent is removed in vacuo and the residue is chromatographed (silica gel, dichloromethane/ethanol 95:5) to give 2.69 g of 4-(2-methoxyphenyl)pyrazole (68%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06730792B2 |
| 出典データセット | uspto-grants-2004_05 |
| ORD ID | ord-5eed3c7b1660419eb4b7d03afb07a3e3 |
| 出典メモ | uspto-grants-2004_05 |