BISOPROLOL FUMARATE → Bisoprolol

HRID 1581900Notes

Reaction equation

HRID 1581900 reaction equation
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:3].C(/C(O)=O)=C\C(O)=O>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:1]

Participants

3

Reactant 1

HCID 6917733BISOPROLOL FUMARATE

Product 1

HCID 2405Bisoprolol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of bisoprolol was prepared as follows. To 529.2 g of purified water were added 180 g of bisoprolol fumarate 2:1. The mixture was stirred for 10 minutes to dissolve the drug. 10.8 g of talc USP (Whitaker, Clark and Daniels Inc., South Plainfield, N.J., USA) were added to the solution and the mixture was stirred for 20 minutes.

Workup

  1. dissolutionto dissolve the drug
  2. stirringthe mixture was stirred for 20 minutes

Sources & evidence

ORD record
ord-481f489f89154a1d87d9b2d300813349
Source dataset
uspto-grants-2004_05
Patent number
US06733789B1

Reaction notes

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