HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(6-Aminohexyl)-2-nitrobenzenesulfonamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 6-{[(2-nitrophenyl)sulfonyl]amino}hexylcarbamate | HCID 53921292 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(6-Aminohexyl)-2-nitrobenzenesulfonamide Hydrochloride | HCID 22719658 | 95% |
Reaction Steps
To a stirred solution of [6-(2-Nitrobenzenesulfonylamino)-hexyl]-carbamic acid t-butyl ester (2.0 g, 4.9 mmol) in 25 mL of methylene chloride at room temperature was added 3 mL of saturated HCl solution in ethyl acetate and stirred for 4 h. The precipitated solid was filtered to yield the titled compound as white solid (1.58 g, 95%); mp 161-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734182B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-edfbf7c596814175b8813359500146e3 |
| Source note | uspto-grants-2004_05 |