反应详情

To a solution of 1-naphthalenemethylisothiocyanate (2.8 g, 13.6 mmol) in 100 ml of MeOH-THF solution (1:1 mixture) was added 4-aminomethylpiperidine (3.1 ml, 27.0 mmol) in a portion and the resulting solution was stirred at reflux for 12 h. The reaction mixture was concentrated in vacuo, yielding oily mixture which was subjected to column chromatography (10% MeOH/CHCl3) to yield 2.3 g (48%) of the desired product as an oil.

1. temperatureat reflux for 12 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. customyielding oily mixture which