Formamide → HCID 178439799, compound

HRID 1581983Notes

Reaction equation

HRID 1581983 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH:12]([CH3:14])[CH3:13])[C:6]=1[C:7](OCC)=[O:8].[CH:15]([NH2:17])=O>>[OH:8][C:7]1[C:6]2[C:5]([CH:12]([CH3:14])[CH3:13])=[CH:4][S:3][C:2]=2[N:1]=[CH:15][N:17]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 2756460Ethyl 2-amino-4-(1-methylethyl)-3-thiophenecarboxylate

Product 1

HCID 178439799HCID 178439799, compound

Procedure

Using ethyl 2-amino-4-isopropylthiophene-3-carboxylate (800 mg, 3.8 mmol) and formamide (5 ml), a similar procedure to a) in Example 19 was carried out to obtain 4-hydroxy-5-isopropylthieno[2,3-d]pyrimidine (330 mg, 1.7 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-0fdba8071e034336bcdb642d508647d1
Source dataset
uspto-grants-2004_05
Patent number
US06734180B1

Reaction notes

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