HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 1-[2-(Hydroxyamino)-2-phenylethanesulfonyl]-4-(4-fluorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Styryl[4-(4-fluorophenyl)piperazino] sulfone | HCID 882266 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2-(Hydroxyamino)-2-phenylethanesulfonyl]-4-(4-fluorophenyl)piperazine | HCID 11176421 | — |
Reaction Steps
To a solution of 1-(4-fluorophenyl)-4-(trans-β-styrenesulfonyl)piperazine (620 mg, 1.79 mmol) in THF (20 ml) was added hydroxylamine (3 ml, 50% aqueous solution). The mixture was stirred for 18 hours. The solvent was evaporated. The residue was dissolved in dichloromethane and washed with water. The organic layer was dried on MgSO4 to give 1-[2-(hydroxyamino)-2-phenylethanesulfonyl]-4-(4-fluorophenyl)piperazine (730 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734184B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-bd69f4efa3494947a57dded1471587ec |
| Source note | uspto-grants-2004_05 |