Trifluoroacetic acid → HCID 9843214, compound

Participants

Reaction Steps

To a solution of N-(2,4-dimethoxybenzyloxy)-3-[4-(4-fluorophenyl)piperazine-1-sulfonyl]-2-isobutylpropionamide (220 mg) in dichioromethane (4 ml) was added trifluoroacetic acid (200 μl) andtriethylsilane (145 μl). The mixture was stirred at room temperature for 15 minutes, evaporated in vacuo and the residue was purified on silica gel (eluant: dichloromethane-ether-methanol (80:20:0.5) to dichloromethane-methanol (80:20) to give the title compound (88 mg, 56%).

Provenance & Evidence